Back issues No.3 - 1997 / Case Report  

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Lymphomatoid Granulomatosis
Yi-Quang Lin, Kao-Chia Yang
Dermatol Sinica 15: 200-206, 1997

A 20-year-old male patient presented with several erythematous papulees and plaques, between 0.5 and 1.5cm in size, sepontaneously arising on the trunk and extremities during the past 3 years. Some of them resulted in ulcers. They occurred off and some healed spontaneously with scars. Skin histopathology revealed many angiocentric and angiodestrucive polymorphous infiltrates in the dermis consisting of small to medium-sized lymphocytes and hisiocytes. Many lymphocytes were atypical. They invaded and destroyed the walls of smalll blood vessels, and resulted in the formation of thrombosis. Periappendageal polymorphous infiltration was characteristically noted. Immunohistochemistry revealed that most of the lymphocytes were UCHL-1(+) and only a minority were L-26(+). Based on the histopathology and clinical characteristics, lymphomatoid granulomatosis was diagnosed. The patient had no malaise, fever, weight loss or any respiratory tract symptoms. The findings of CXR were within normal limits. Later all the ulcers healed spontaneously without treatment and no new lesions developed.

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