Back issues No.4 - 1997 / Case Report  

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Purely Cutaneous Rosai-Dorfman Disease Case Report and Review of the Literature
Yen-Liang Chem, Tsuo-Wu Lin, Shiou-Feng Huang, Tsen-Fang Tsai
Dermatol Sinica 15: 290-295, 1997

Rosai-Dorfman disease is an uncommon disease affecting individuals of either sex and of all ages. Cutaneous lesions of Rosai-Dorfman disease are usually associated with nodal or other extranodal localization. Purely cutaneous Rosai-Dorfman disease is rare. We present a 33-year-old woman with Rosai-Dorfman disease clinically limited to the skin. The patient presented with a 14x10 cm dark brownish, irregularly shaped plaque with many subcutaneous nodules on her right thigh. Histology showed nodular infiltrate composed of plasma cells and large foamy histiocytes with scattered lymphophagocytosis in the dermis and hypodermis. The histiocytes were positive for S-100 protein by immunohistochemical study. Published cases of purely cutaneous Rosai-Dorfman disease are also reviewed.

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