Back issues No.2 - 1999 / Case Report  

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Generalized Hair Follicle Hamartoma Associated with Systemic Lupus Erythematosus
Hung-Wen Kuo, Cheng-Hung Lin, Ji-Chen Ho, Shun-Chen Huang
Dermatol Sinica 17: 184-190, 1999

A 60-year-old Taiwanese women with a 7-year history of systemic lupus erythematosus presented with infiltrative papules and plaques on her face and ears for 6 months, and progressive loss of the scalp, eyebrow, axillary, and pubic hairs and lower eyelashes for 6 years. Histologic sections taken from the right nasolabial fold and right ear demonstrated anastomosing cords and islands of basaloid cells in the dermis embedded in a cellular stroma, and some hair bulb-like structures were noted in the tumor islands. The histopathological findings of the hairless, mildly indurated scalp demonstrated similar islands of basaloid cells in the dermis, which appeared to be related to the pilosebaceous follicles. Therefore we made the diagnosis of generalized hair follicle hamartoma, a very rare condition usually associated with autoimmune diseases.

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