Back issues No.3 - 1999 / Case Report  

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Primary Cutaneous Large B-Cell Lymphoma of the Leg
Ching-Ya Wang, Hsien-Ching Chiu
Dermatol Sinica 17: 215-219, 1999

A 73-year-old male patient presented with a 2-year history of a symptomless, solid tumor on his left shin. The tumor progressively enlarged along with development of smaller satellite lesions near the main mass. Histopathological examination showed diffuse infiltration of large atypical cells in the dermis consistent with diffuse large cell lymphoma, and immunohistochemical studies revealed that these cells were L26 positive. Serial staging procedures disclosed a suspicious 1 cm-sized lymph node in the left supraclavicular fossa. A diagnosis of primary cutaneous large B-cell lymphoma of the leg (according to EORTC classification of cutaneous B-cell lymphomas) was made. The patient was treated with 3 monthly courses of polychemotherapy, and has been in complete remission thereafter.

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