Back issues No.3 - 1999 / Case Report  

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Langerhans Cell Histiocytosis in a Patient with Psoriasis
Chan-Ho Lai, Tseng-Tong Kuo, Lih-Jen Yang, Wen-Rou Wong, Heng-Leong Chan
Dermatol Sinica 17: 220-224, 1999

We report a rare association of Langerhans cell histiocytosis (LCH) with psoriasis vulgaris. A 68-year-old diabetic woman was admitted under the impression of pulmonary miliary tuberculosis. She had two types of skin lesions. One of them was characterized by generalized erythematous to purpuric crusted papules on the trunk and limbs for more than one year. The other type was typical psoriatic lesions present for more than 8 years. Both types of skin lesions were pruritic. A skin biopsy of the former lesion showed LCH. It was confirmed by CD1a staining on immunohistochemical study. The second type of skin lesion was confirmed histopathologically as psoriasis. The pulmonary lesions were not due to LCH. The skin lesions were treated by topical steroid. The association of LCH and psoriasis has only been reported once before.

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