Adult T-Cell Leukemia/Lymphoma with Skin Eruption and Mediastinal Involvement
Yuan-Hsin Lo, Yang-Chih Lin, Hsiu-Chin Chen, Hsin-Yi Su, Ming-Chih Chung
Dermatol Sinica 17: 242-247, 1999

We report a case of adult T-cell leukemia/lymphoma (ATLL) with extraordinary mediastinal lymphadenopathy. A 48-year-old woman presented with inguinal and cervical lymphadenopathy,significant weight loss, and subsequent diffuse cutaneous eruption. Laboratory data revealedhypercalcemia, leukocytosis with atypical lymphocytes, multilobulated cells in the peripheral blood, and a positive anti-human T lymphotropic virus type I (HTLV-I) antibody test. The results of the biopsies of the skin and lymph nodes revealed infiltration of atypical lymphocytes. Her condition deteriorated and she died of respiratory failure seven months after her initial presentation.