Back issues No.4 - 1999 / Case Report  
 
 

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POEMS Syndrome -A Case with Three-Year Follow-Up-
Yang-Shia Dai, Hsien-Ching Chiu
Dermatol Sinica 17: 334-338, 1999

We report a typical case of POEMS syndrome manifesting progressive weakness and numbness of bilateral lower legs, abnormal level of thyroid stimulating hormone, estrogen and testosterone, hepatosplenomegaly, M-protein and cutaneous changes. Hypertrichosis,hyperpigmentation, and sclerodermoid change of the skin appeared insidiously along with the onset of the neurological symptoms. Cutaneous angiomas were also noted in this patient, which developed abruptly about six months after the onset of the illness. Microscopically, they showed ectatic vessels in the dermis without proliferation of the endothelium. Two years and six months later, a plasmacytoma was found in the right femoral head. The cutaneous hyperpigmentation responded well to eradication of the plasmacytoma, and the angiomas totally disappeared after plasma exchange and prednisolone treatment. However, the polyneuropathy remained the same.

   
   
 
 
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