Back issues No.3 - 2000 / Case Report  

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Pemphigus Vegetans- A case report -
Dong-Jia Tsai, Tien-Yi Tzung, Tsu-Chyang Chen
Dermatol Sinica 18: 197-203, 2000

A 71-year-old male had generalized bullous lesions and oral ulcers 15 years ago. Pemphigus vulgaris was confirmed by skin biopsy and immunofluorescence study. He received treatment with oral prednisolone and azathioprine and had good response. In May 1998, an erosive, verrucous, vegetative plaque was noted over vermilion border of the lip and left side of perineum. Histopathologic examination showed suprabasal acantholysis and intraepidermal microabscesses containing numerous eosinophils. Direct immunofluorescence study of lesional and perilesional skin revealed intercellular deposition of IgG in the epidermis. Pemphigus vegetans was diagnosed by the clinical and laboratory findings. The skin lesions subsided after increasing the dose of oral medication.

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