Back issues No.3 - 2000 / Case Report  

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Pyoderma Gangrenosum Associated with Myelodysplastic Syndrome
Tsu-Man Chiu, Kao-Chia Yang, Cheng-Shyong Chang
Dermatol Sinica 18: 211-218, 2000

Pyoderma gangrenosum(PG)is an uncommon, ulcerative, cutaneous disorder with distinctive clinical characteristics. We report a 62-year-old woman who had had extensive painful ulcers over bilateral calves for 11 months when she was admitted to our hospital. Although she had been treated as having infectious ulcers(including surgical excision)at other hospitals, but the ulcers continued to aggravate. According to the findings from the skin biopsy, the microbial culture results, the characteristics of the ulcers, and the clinical course, she was diagnosed to have pyoderma gangrenosum. With systemic steroid treatment, the ulcers healed gradually and the painful sensation was greatly relieved. Therefore she was discharged and being followed at OPD. However she was readmitted 2 days later due to fever and pancytopenia. With further examinations, she was diagnosed to have Klebsiella pneumoniae pneumonia and myelodysplastic syndrome(MDS). Under treatment with antibiotics and systemic steroid, the condition of the lung was improved and the ulcers healed gradually, leaving cribriform scars. In this report, we will discuss the relationship between PG and MDS.

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