Back issues No.3 - 2000 / Case Report  

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Transient Acantholytic Dermatosis (Grover's disease)- A case report -
Yu-Wen Cheng, Yao-Kun Chiu, Ji-Chen Ho, Wei-Jen Chen
Dermatol Sinica 18: 229-234, 2000

We herein report a case of transient acantholytic dermatosis (TAD) occurring in a patient with lung abscess. He developed pruritic erythematous papules and papulovesicles on the trunk and upper arms on the fifth hospital day. The histology of skin biopsy showed small circumscribed blisters with a pemphigus vulgaris-like pattern. Under medical treatment, he became afebrile on the tenth hospital day. In the mean time, oral antihistamine and topical steroid cream were prescribed for the skin lesions and the eruption cleared in two weeks. Serial sectioning of the biopsy specimen revealed that the two suprabasal blisters were simultaneously associated with the acrosyringium. The clinicohistologic findings in this case favor a relationship with heat and sweating, as suggested by some authors. To our knowledge, this case of TAD is the first documented one in Taiwan. The rare reported cases of TAD in Taiwan might be due to low prevalence of this disorder among Orientals and/or to unfamiliarity with it. When confronted with cases of TAD, serial sectioning of the biopsy specimen is suggested to delineate the association of the lesions with the acrosyringium.

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