Back issues No.3 - 2000 / Case Report  

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Papular Xanthoma in Children- A case report -
Dong-Jia Tsai, Tien-Yi Tzung, Tsu-Chyang Chen
Dermatol Sinica 18: 239-244, 2000

A 1-year-7-month-old boy had several asympatomatic papular eruptions, particularly on the face, that initially developed at 6 months of age. Individual lesions were yellow to yellow-brownish. New lesions continued to develop over the trunk and limbs in one year. Skin biopsy showed aggregation of foamy histiocytes in the dermis. These cells were positive for CD68, but negative for CD34 and S-100 protein. Periodic acid-Schiff (PAS) stain was negative. Sudan black B and oil-O stains were positive on frozen section. The electron microscopic studies revealed that the foamy cells contain lipid vacuoles and some incomplete laminated bodies. Birbeck granule is absent. The serum levels of total cholesterol and triglyceride were within normal limits. Sonography of upper abdomen and chest X-ray showed no abnormal finding. Based on the clinical and laboratory findings, papular xanthoma was diagnosed.

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