Back issues No.4 - 2000 / Case Report  

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Prurigo Pigmentosa-A Report of Four Cases-
Chia-Jung Hsiao, J. Yu-Yun Lee, Hamm-Ming Sheu
Dermatol Sinica 18: 311-315, 2000

Prurigo pigmentosa (PP) is an uncommon skin disease characterized by a pruritic reticulated erythematous papular eruption that leaves a mottled hyperpigmentation after resolution. To date, only 2 cases were reported from Taiwan. In this report, we describe four cases of PP with typical clinical features and dramatic therapeutic response to minocycline. Histopathologically, characteristic findings of PP, namely vacuolar alteration of the basal cells, spongiosis, necrosis of keratinocytes, exocytosis of lymphocytes and a patchy lichenoid or lichenoid predominantly lymphocytic and occasionally eosinophilic infiltration were observed. However, two unusual new findings were noted in 3 cases; one case showed extensive necrosis of keratinocytes as well as reticulate degeneration resulting in intraepidermal vesicles, the other two cases displayed lymphocytic nuclear dust in the epidermis.

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