Back issues No.4 - 2000 / Case Report  

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Sclerosing Perineurioma
Chia-Yu Chu, Tsen-Fang Tsai, Guang-Hsiang Hsiao, Cheng-Hsiang Hsiao
Dermatol Sinica 18: 322-328, 2000

Perineurioma is a rare tumor originated from perineurium. In electron microscope, the perineurial cell is characterized by the presence of external lamina, occasional pinocytotic vesicles, scattered intermediate filaments and electron-dense cell membrane plaques. Immunohistochemically, the perineurial tumor cells are reactive for vimentin and epithelial membrane antigen (EMA) but negative for S-100 protein. Sclerosing perineurioma is a recently described variant of perineurioma with distinctive clinical and histopathologic features. It typically presents as a small, painless, dermal or subcutaneous mass involving the digits and palms of young adults. Histopathologically, it showed abundant, thick, collagen bundles and scattered small epithelioid or spindled cells with corded, trabecular or whorled (onion bulb-like) growth patterns. We herein report two cases of sclerosing perineurioma. Previously published cases in English language literature are also reviewed.

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