Back issues No.3 - 2001 / Case Report  

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Hydroxyurea-induced Symmetrical Lower Leg Ulcers—A Case Report—
Sung-Jan Lin, Tsen-Fang Tsai, Cheng-Hsiang Hsiao
Dermatol Sinica 19: 249-254, 2001

Hydroxyurea is commonly used to treat chronic myeloproliferative disorders. Lower leg ulcer is a recently identified cutaneous adverse effect of long-term hydroxyurea therapy. We present a case of symmetrical painful lateral malleolar ulcers in a polycythemia vera patient who had been treated with hydroxyurea for 6 years. Histologically, the ulcer showed diffuse dermal fibrosis without vasculitis. The ulcer was recalcitrant despite topical treatment, but it resolved completely in one month after hydroxyurea was discontinued. Hydroxyurea-induced lower leg ulcer is a unique clinical entity that necessitates early recognition and prompt discontinuation of hydroxyurea.

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