Back issues No.4 - 2001 / Original Study  

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Sonophoresis with 20% L-Ascorbic Acid and 2% Kojic Acid Gel for the Melasma Patients
Shih-Hung Lee, Chun-Min Wang, Chi-Jung Chung, Hong-Shang Hong
Dermatol Sinica 19: 275-281, 2001

We treated 17 female patients of melasma by using ultra-sonic equipment with 20% L-ascorbic acid, which contain 2% kojic acid gel. Each patient received a treatment of 15-minute sonophoresis twice weekly for 5 weeks. Regular photographs and UV photographs were taken before and after the course of treatment. The dermatologist read the result finally. All patients completed a questionnaire to evaluate the improvement of pigmented lesions, skin color, skin texture, wrinkles at the end of the treatment course. Photographs noted no significant improvement of pigmented lesions but improvement of skin texture and skin color. No patient complained of adverse reactions during or after the treatment. Through our patients' evaluation, the satisfaction of treatment for the skin texture is better than that for pigmented lesions, skin color, and wrinkles. The method provides an alternative for people seeking better skin texture. Patients may feel facial skin color lightening if skin texture improved. Thus, it may be also an adjunctive therapy for melasma.

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