Back issues No.4 - 2001 / Case Report  

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Acantholytic Acanthoma -Two Case Reports-
Wen-Chin Yu, Yi-Hun Liao, Tsen-Fang Tsai, Guang-Hsian Hsiao, Cheng-Hsian Hsiao
Dermatol Sinica 19: 345-350, 2001

Acantholytic acanthoma is a benign acanthoma unrecognized previously, which was first described by Brownstein in 1985. Here we report two cases of acantholytic acanthoma, the first case was a 62-year-old male patient presented with one erythematous, hyperkeratotic, rice grain-sized papule with elastic, firm consistency over his left axilla for several months. Histopathological examination of excisional biopsy revealed focal acanthosis with suprabasal clefts and intraspinous acantholysis of epidermis. The second case was a 68-year-old female patient presented with one brownish, bean-sized, hyperkeratotic plaque on her right upper arm for several months without any symptom. Microscopic study showed hypergranulosis and acanthosis with prominent suprabasal clefts and intraspinous acantholysis of epidermis. Both of these two cases were typical acantholytic acanthoma with characteristic histopathologic features and differentiations from other disease with acantholytic dyskeratosis were also made.

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