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Serum Level of Squamous Cell Carcinoma Antigen as a Marker of Disease Activity in Patients with Psoriasis
Chia-Chi Shih, Gwo-Shing Chen, Roger Chin-Che Hsu, Chih-Hung Lee, Shiang-Bin Jong
Dermatol Sinica 20: 1-6, 2002

Squamous cell carcinoma antigen (SCC Ag) is a tumor marker for SCC of the uterine cervix. Recently, serum levels of SCC Ag were noticed to be elevated in patients with benign dermatoses. In this study, we investigated SCC Ag levels in 47 patients with psoriasis to determine whether this Ag is a useful marker of disease activity. Our results demonstrated that patients with pustules, erythroderma and poor control status showed higher serum levels of SCC Ag. A positive correlation of SCC Ag with the percentage of body surface and psoriasis area and severity index (PASI) score was found. These data suggest that SCC Ag levels may be an indicator of psoriasis activity. Furthermore, the biological roles of SCC Ag in the squamous cells are discussed

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