Back issues No.1 - 2002 / Case Report  

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Angiomatoid Malignant Fibrous Histiocytoma—A Case Report—
Jeng-Hsien Lin Kong-Chao Chang Wen-Chieh Chen Jui-Chin Yu
Dermatol Sinica 20: 7-12, 2002

Angiomatoid malignant fibrous histiocytoma (AMFH) is a rare, low-to-intermediate-grade malignant tumor that occurs primarily in the extremities of young individuals. A 23-year-old woman had a slow-growing violaceous tender firm papule at left palm for 1 year. Histopathology showed characteristic findings of AMFH, namely (1) irregular solid masses and nodules of fibroblast-and histiocyte-like cells, (2) focal areas of hemorrhagic cysts and (3) chronic inflammatory infiltrate consisted mainly of lymphocytes and plasma cells, forming lymphoid follicles. The tumor cells were focally positive for CD68 immunostaining, suggesting possible histiocytic origin. Wide excision deep to the subfascial layer and with a safety margin of 1cm was performed, and the skin defect was covered with a free groin flap. We present the case and review the literature. Differences to malignant fibrous histiocytoma are also compared.

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