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Cutaneous manifestations in a patient withWerner syndrome —Case Report and Literature Review—
Yi-Ju Chen Chih-Chao Yang Chia-Yu Chu Yang-Shia Dai Chee-Ching Sun
Dermatol Sinica 20: 74-83, 2002

Werner syndrome is a rare autosomal recessive disorder that manifests as genetic instability as well as early onset of aging-related diseases. Patients with Werner syndrome develop aged appearance and graying of hair at young age. Other characteristic features include bilateral congenital cataracts, scle-rodermoid skin changes, short stature, diabetes mellitus, hypogonadism, osteoporosis, atherosclerosis and various types of cancer. There are also florid cutaneous manifestations in WS. We herein report the cutaneous manifestations and histopathologic findings of a 25-year-old female with Werner syndrome. This is the first known reported case of Werner syndrome in Taiwan.

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