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Classical Kaposi's Sarcoma of the Glans Penis Effectively Treated with Low-dose Intralesional Vinblastine Injection—A Case Report—
Shu-Fen Lee Tak-Wah Wong J.Yu-Yun Lee
Dermatol Sinica 20: 218-222, 2002

Classical Kaposi's sarcoma (KS) is a multicentric cutaneous and extracutaneous vascular neoplasm predominantly affecting older individuals, immunosuppressed patients and homosexual men. Although KS of the genitalia is not rare event, it is challenging to treat multiple KS of the glans penis. Localized KS may be treated by excision, radiation, cryotherapy and intralesional injection of interferon-alpha or cytotoxic chemotherapy. Although intralesional injection of vinblastine has been used to treat oral KS successfully, little is known about its efficacy in treating glanular KS. We report a 56-year-old man with isolated, classical KS involving his glans penis. The tumors were treated with 6 biweekly intralesional vinblastine injections (0.2 mg/ml, 1 ml/dose) after regional anesthesia. The tumors showed about 70% reduction in size after one injection and were almost completely resolved after 4 treatments. There was no obvious side effect. The patient remained tumor-free 18 months later. The favorable response in our case suggests that intralesional low-dose vinblastine injection could be an effective alternation for treating glanular KS.

   
   
 
 
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