Back issues No.2 - 2003 / Case Report  

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Intradermal Urate Tophi—Report of 6 Case
I-Shu Chen, Hung-Wen Kuo, Ji-Chen Ho
Dermatol Sinica 21 : 146-152, 2003

Intradermal urate tophi are rare skin manifestations of chronic gout. They appear as small, superficial, pustule-like, whitish lesions. Histologic features show multiple, intradermal foci of amorphous deposits surrounded by mononuclear cells and multinucleated giant cells. Renal insufficiency, hypertension, and chronic glucocorticoid use may be associated with the development of intradermal tophi. The occurrence of intradermal tophi appears to correlate with advanced disease. We report on 6 cases of intradermal tophi and review the literature on this disorder, which includes a rare case of combined psoriasis and intradermal tophi.

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