Back issues No.2 - 2003 / Case Report  

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Cutaneous Mycobacterium kansasii Infection in a Patient with Systemic Iupus Erythematosus: Diagnosed by Genotyping and Phenotyping
Jeng-Wei Tjiu , Yu-Chih Lin Chii-Shyan Wang , Hsien-Ching Chiu
Dermatol Sinica 20 : 160-164, 2003

Mycobacterium kansasii infections of the skin are rarely seen and present variable clinical and histologic features. Most patients with M. kansasii infection have altered immunity, caused either by immunosuppressants or underlying diseases. Laboratory identification of the organism is essential for proper diagnosis and selection of appropriate antimycobacterial medication. We report cutaneous M. kansasii infection in a patient with systemic lupus erythematosus. DNA was extracted from skin biopsy specimen and a portion of HSP65 gene was amplified by polymerase chain reaction(PCR). The DNA sequence of the amplified product was compatible with that of M. kansasii. Culture of the skin biopsy specimen also yielded M. kansasii in 8 weeks. Treatment including isoniazid, ethambutol and rifampin was insititued right after the diagnosis was established. No new lesions have been noted for three months after initiation of the three combined therapy.

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