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Progressive Symmetric Erythrokeratodermia‚ÄĒA Case Report
Shu-Feng Kan, Chung-Hong Hu, Woan-Ruoh Lee
Dermatol Sinica 21 : 175-179, 2003

Progressive symmetric erythrokeratodermia (PSEK) is a rare disorder of cornification characterized by epidermal hyperproliferation and is inherited as an autosomal dominant trait with variable penetrance. However, it has been reported that sporadic mutations comprise of 40 percent of all cases. Patients with PSEK usually respond to oral retinoid or etretinate therapy. We report a case of progressive symmetric erythrokeratodermia that was recalcitrant to oral acitretin and topical steroid, urea and tretinoin, as well as calcipotriol.

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