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Balloon Cell Melanoma Mimicking Hemangioma-A Case Report And the Literature Review
Yuan-Yue Hou , Shih-Tsung Cheng , Roger Chin-Che Hsu, Gwo-Shing Chen
Dermatol Sinica 21: 280-285, 2003

Abstract
Balloon cell melanoma is a rare histological variant of all melanoma. Histopathological interpretation of this tumor could be difficult, especially when the lesions contain little or no pigment. In order to diagnose balloon cell melanoma the foamy cells have to constitute more than 50% of tumor cells. Herein, we report a male whose lesion first appeared as a banal papule on the right hand, then evolved into some uncanny violaceous-brownish noduloplaques. Initial clinical and pathological diagnosis was hemangioma; however, the prominent foamy cells were noticed. Special stains disclosed positive reactivity with HMB-45 and S-100. The deltopectoral and axillary lymph nodes dissection verified lymph node metastases. The final diagnosis is balloon cell melanoma with lymph nodes metastases. After surgical excision, lymph nodes dissection and two courses of chemotherapy, the patient is alive and free of disease 2 years after diagnosis. A review of literature comparing the prognostic significance or metastatic propensity of balloon cell melanoma with other more common types of melanoma revealed no significant difference.

   
   
 
 
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