Back issues No.1 - 2004 / Original Study  

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Evaluation of Allergen-Specific IgE Antibodies by MAST in Atopic Dermatitis
Yuh-Ru Huang, Hamm-Ming Sheu
Dermatol Sinica 22 : 1-14, 2004

Background: Increased serum total IgE and specific IgE antibody to ingested or inhaled antigens are one of the main immunological abnormalities in atopic dermatitis(AD). Dietary factors and a variety of inhalants have been implicated in exacerbation of AD. Purpose: The purpose of the present work is to elucidate the prevalence of inhalant, food, fungal and plant allergens in patients with AD in southern Taiwan. Methods: We collected serum samples from 507 patients with AD who were treated at National Cheng Kung University Hospital. In this study, 35 allergen-specific immunoglobulin(IgE) antibodies were evaluated by Multiple-antigen simultaneous test(MAST). Total IgE antibodies in serum samples form subjects were measured by the N Latex IgE mono assay. Results: The results reveal the positive rates of the allergens detected by the MAST system are 60.2% for Dermatophagoides farinae, 59% for Dermatophagoides pteronyssinus, 44.2% for house dust, 34.7% for cockroach, and 21.3% for milk. The IgE antibody level is low in infantile group and high in adolescent/young adult group. The younger children start with allergy to food allergens. Egg white and milk are the most common sensitizers. Allergy to inhalant and fungal allergens is rare in the first two years, and gradually increases at adolescent/young adult age. Allergy to plant allergens increases with age. Conclusion: The results indicate that mite and foods are the major sensitizing allergens in Taiwan. The prevalence of allergens in various age groups of AD in Taiwan is similar to those in western countries.

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