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Vitiligo Universalis Associated with Evans Syndrome and Antiphospholipid Syndrome—A Case Report and Review of the Literature
Chih-Hsiung Yang, Chia-Yu Chu, Sung-Jan Lin
Dermatol Sinica 22 : 93-99, 2004

The pathogenesis of vitiligo has been proposed as a destruction of melanocytes by autoimmune processes. Evans syndrome is the combination of autoimmune hemolytic anemia and immune-mediated thrombocytopenia. The antiphospholipid syndrome is characterized by arterial/venous thrombosis, recurrent pregnancy loss, or thrombocytopenia in the presence of antiphospholipid antibodies. We present a case of vitiligo universalis associated with Evans syndrome and antiphospholipid syndrome, the association of which has not been reported before. The association of multiple autoimmune diseases in our case also support the theory that vitiligo may result from immune dysregulation.

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