Back issues No.3 - 2004 / Case Report  

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Ichthyosis Hystrix of Curth-Macklin
Hung-Hsu Yang , Nan-Lin Wu , Yang-Chih Lin , Yu-Hung Wu
Dermatol Sinica 22 : 239-242, 2004

Ichthyosis hystrix of Curth-Macklin (IHCM) is an extremely rare keratinization disorder, with verrucous to hystrix-like hyperkeratotic plaques of varying extent. The diagnosis is based on a distinctive pattern of epidermolytic hyperkeratosis and the presence of binucleate cells under light microscopy, as well as unique electron microscopic findings of continuous perinuclear tonofibril shells in the suprabasal keratinocytes. We present the clinical manifestation and light and electron microscopic findings in a 23-year old male patient with IHCM.

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