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Medium-dose UVA1 as a Monotherapy for Moderate to Severe Atopic Dermatitis — Primitive Results of a Monocenter Trial in Taiwan
Chi-Bin Lin , Yi-Lang Hsu , Tien-Yi Tzung
Dermatol Sinica 24:102-109,2006

Long-wavelength ultraviolet A (340-400 nm: UVA1) phototherapy is known to be
effective in the treatment of acute exacerbation of atopic dermatitis. However, little
has been mentioned in the literature concerning the therapeutic efficacy and possible
side effects of UVA1 phototherapy in Asian patients with atopic dermatitis.
Medium-dose (50-100J/cm2) UVA1 phototherapy was used to treat 21 Chinese
patients with acute moderate to severe atopic dermatitis for 15 times (5 times per
week). After 3 consecutive weeks of treatment, they were followed up for another 4
weeks. The results showed that UVA1 phototherapy notably reduced the mean scores
of investigator’s global assessment (IGA, from 3.9 to 1.9) and eczema area and
severity index (EASI, from 30.1 to 10.3) as well as the visual analogue scale (VAS) of
pruritus and sleep disturbance after 3 weeks of treatment. However, burning sensation,
dryness and skin tanning were often observed during the treatment phase. Moreover,
the short maintenance effect of UVA1 monotherapy was complained by 18 patients
and thus compromised their satisfactions at the end of follow-up.

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