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Comparative in vitro activity of six topical antiseptics to Pseudomonas aeruginosa
Chih-Kun Lo , Han-Nan Liu , Kwok-Woon Yu
Dermatol Sinica 24:230-7,2006

Abstract
Concomitant infection of Pseudomonas aeruginosa in toe webs is a rather common phenomenon in dermatophytosis complex. Because of the ever increasing resistant strains of Pseudomonas aeruginosa against antibiotics, and compromised circulation the affected patients frequently possess, the antibiotic therapies always face the challenge of winning the battle. Previous treatment strategies of soaking the affected feet in several antiseptics including acetic acid, benzalkonium chloride solution, or potassium permanganate solution did not yield satisfactory or consistent results. It remains to be determined whether the use of these antiseptics is justified. Therefore we added three candidate antiseptics- sodium hypochlorite solution, propolis, and povidone-iodine solution- to the treatment strategies and compared in vitro the antibiotic activities against Pseudomonas aeruginosa. We intended to know whether the antiseptics used in the past were effective and meanwhile exploring new potential antiseptics for the treatment of dermatophytosis complex. Our study showed that povidone-iodine solution as well as sodium hypochlorite solution with the concentration greater than 0.125% was bactericidal. The use of these two antiseptics in the treatment of dermatophytosis complex seems to be promising. Acetic acid was less effective. With the concentration greater than 0.125%, it could inhibit the growth of Pseudomonas aeruginosa (bacteriostatic). On the contrary, higher concentrations were needed for benzalkonium chloride solution, potassium permanganate solution, and propolis to inhibit the growth of Pseudomonas aeruginosa and they are probably not suitable candidate antiseptics for treating dermatophytosis complex.

   
   
 
 
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