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Inflammation and Progression of Skin Basal Cell Carcinoma-With Emphasis on Interlenkin-6, Cyclooxygenase-2 and CXCR4
Shiou-Hwa Jee
Dermatol Sinica 24:247-255,2006

縮寫: Akt, acutely transforming retrovirus AKT8 in rodent T cell lymphoma; bFGF, basic fibroblast growth factor; CSF-1, colony stimulating factor; HGF, hepatocyte growth factor; IGF, insulin-like growth factor; MCP-1, monocyte chemotactic factor-1; MMP, matrix metalloproteinase; SDF-1, stromal cell derived growth factor ; STAT3, signal transducer and activator of transcription 3; TGFβ, transforming growth factor β; TNF, tumor necrosis factor ; uPA, urokinase plasminogen activator
細胞介白質-6 (interleukin-6, IL-6)、環氧脢-2 (cyclooxygenase-2, COX-2)、及CXCR4是發炎反應及惡性腫瘤都相關媒介物質。本文將以在台灣細胞介白質6, 環氧脢-2、及CXCR4對皮膚基底細胞癌(basal cell carcinoma, BCC)進展(progression) 相關之研究論文為藍本,涵蓋惡性腫瘤機制中致癌力、抗細胞凋亡能力、血管新生能力及其訊息傳遞,以介紹發炎與皮膚基底細胞癌之進展機轉。

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