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Elevated Serum Tissue Polypeptide Antigen in a Patient with Mycosis Fungoides
Chu-Sung Hu , Chi-Ling Lin , Gwo-Shing Chen , Cheng-Che Lan
Dermatol Sinica 25 : 67-72, 2007

Tissue polypeptide antigen (TPA) is a tumor marker which has been found to be elevated in various solid tumors, including cancers of the lung, breast, and bladder. However, there have been very limited reports regarding the association of this tumor marker with hematologic malignancies. We here report a patient with mycosis fungoides (MF), presenting with generalized scaling involving >90% of the total body surface area, erythema of buttocks and thighs, bilateral inguinal lymphadenopathy, and atypical lymphocytes found in the peripheral blood. A series of tumor markers were found to be within normal limits except TPA, which was elevated three times above the upper normal limit. The presence of another primary tumor was excluded by history taking, physical examination, blood tests, and various radiological and nuclear imaging. Following two courses of chemotherapy, the patient’s skin condition improved, and her serum TPA level returned to normal. These findings suggest that serum TPA may prove to be clinically significant in a subset of patients with mycosis fungoides.

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