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Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Retrospective Analysis of Southern Taiwanese Population During 2002 to 2007
Chin-Hsin Huang Ji-Chen Ho Yu-Wen Cheng Wei-Ming Wu
Dermatol Sinica 27: 15-26,2009

Background: Stevens-Johnson syndrome(SJS) and toxic epidermal necrolysis(TEN) are severe
adverse drug reaction with potentially life-threatening skin disease. The widely accepted consensus
regarding therapy does not exist at present and epidemiological data of Taiwan in recent
years is limited.
Objective: To evaluate the effi cacy of systemic steroid therapy in treatment of SJS and TEN and
also analysis the associated epidemiology data.
Methods: This study was performed by retrospectively chart review of patients admitted with
SJS or TEN in a tertial referral medical center in southern Taiwan between 2002 and 2007. Clinical
data including mortality, morbidity, the category of offending drugs and the systemic steroid
treatment effects were analyzed.
Results: Total 52 patients were included; 10 were classifi ed as TEN and 42 as SJS. Overall mortality
is 3.8% and infectious morbidity is 23%. In aspect of causative agents, anticonvulsants (especially
carbamazepine) were the most common drugs followed by Non-Steroid Anti-infl ammatory
Drugs, allopurinol and antibiotics in our series. Early systemic steroid administration may
shorten the hospitalization duration than supportive care (p < 0.012) in our study.
Conclusion: In our study, early administration of systemic steroids maybe benefi ts in the forms
of infl ammation prevention and disease progression. Short-term use to preclude infection morbidity,
as well as a tapering dose as soon as possible, is suggested.

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