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Transition from Pemphigus Vulgaris to Pemphigus Foliaceus- Report of Two Cases
Po-Yu Shih Tseng-Tong Kuo Chien-Chun Chiou Jia-Ru Wang Ke-Jen Yu Hsin-Chun Ho Hong-Shang Hong Yue-Zon Kuan
Dermatol Sinica 27: 52-58, 2009

Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two different subtypes of the
pemphigus group with distinct clinicopathologic features. Clinically, PV presents with mucosal,
mucocutaneous, or cutaneous lesions whereas PF lesions are primarily cutaneous. Histopathologically,
intraepidermal acantholysis is located at the granular layer in PF and suprabasally in PV.
Traditionally, these differences are used for basis of treatment selection and prognostic estimation.
However, infrequent transition between the subtypes has been reported. Herein we describe
two cases of PV with transition into PF and discuss the proposed mechanism for this phenomenon.

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