Back issues No.4 - 2009 / Review  

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Severe Cutaneous Adverse Reactions to Drugs (SCAR):Defi nitions, Diagnostic Criteria, Genetic Predisposition
Jean-Claude Roujeau, Laurence Allanore, Yvonne Liss, Maja Mockenhaupt
Dermatol Sinica 27: 203-209, 2009

This paper is a review of the clinical characteristics, diagnostic criteria and main drug
causes of the severe cutaneous adverse reactions to drugs (SCAR) that are studied by the RegiSCAR-
group. These include acute generalized exanthematous pustulosis, drug reaction with
eosinophilia and systemic symptoms (also called drug-induced hypersensitivity syndrome), Stevens-
Johnson syndrome, and toxic epidermal necrolysis.

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