Back issues No.4 - 2009 / Case Report  

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Graft-Versus-Host-Like Disease- A Case of Thymoma-Related Erythroderma
Yu-Ta Yen, Ji-Chen Ho, Cheng-Yu Wang
Dermatol Sinica 27: 241-247,2009

Graft-versus-host disease (GVHD) is a T-cell-mediated reaction that most commonly develops
after transplantation of hematopoietic stem cells. In rare conditions, GVHD-like symptoms
are observed in patients with thymoma. We present the case of a 58-year-old man with thymoma
noted 6 years earlier who initially presented with myasthenia gravis and subsequently developed
GVHD-like disease with symptoms of generalized itching, scaly erythroderma, and liver
dysfunction. The histopathological features of a skin biopsy were consistent with those noted in
the case of GVHD. We assume that the altered thymic microenvironment in thymoma patients
causes immune dysregulation, leading to GVHD-like disease.

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