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Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofl uorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature
Chih-Pin Chen , Richard Plunkett , Raminder Grover , Song-Jen Hong
DERMATOLOGICA SINICA 29 (2011) 55-58

Antiepiligrin cicatricial pemphigoid (AECP) is a chronic autoimmune subepidermal blistering disease
characterized by clinical features of cicatricial pemphigoid and circulating IgG antibasement membrane
autoantibodies directed against laminin 332. There is growing evidence of an increased relative risk for
solid cancers and lymphomas in AECP patients, especially in the 1st year after the onset of blisters.
However, it is difficult to distinguish patients with initially skin-predominant AECP from similar findings
of epidermolysis bullosa acquisita merely based on clinical, histopathologic, and immuno-pathologic
examinations. This is a report on a case of AECP confirmed by indirect immunofluorescence of type
VII collagen- and laminin 332-deficient skin as substrates to differentiate it from epidermolysis bullosa
acquisita.

   
   
 
 
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